Concepedia

N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetration

Florian Wakenhut, Gill Allan, Paul V. Fish, M. Jonathan Fray, Anthony Harrison, Rachel McCoy, Stephen C. Phillips, Alan Stobie, Dominique Westbrook, Simon Westbrook,

Bioorganic & Medicinal Chemistry Letters · 2009 · 13 citations · 16 references

DOIFull text

Open access

Concepts

References

16

Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs

Kelly M. Mahar Doan, Joan E. Humphreys, Lindsey O. Webster et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 626 citations

, , +17

A general pattern for substrate recognition by P‐glycoprotein

Anna Seelig · European Journal of Biochemistry · 1998 · 527 citations

, , +17

Desvenlafaxine Succinate: A New Serotonin and Norepinephrine Reuptake Inhibitor

Darlene C. Deecher, Chad E. Beyer, Grace H. Johnston et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 380 citations · Full text

, , +17

Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers

Michael Skinner, Han‐Yi Kuan, Alan X. Pan et al. · Clinical Pharmacology & Therapeutics · 2003 · 193 citations

, , +17

Duloxetine for the Management of Diabetic Peripheral Neuropathic Pain: Evidence-Based Findings from Post Hoc Analysis of Three Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Studies

Daniel K. Kajdasz, Smriti Iyengar, D. Desaiah et al. · Clinical Therapeutics · 2007 · 141 citations

, , +17