Desvenlafaxine Succinate: A New Serotonin and Norepinephrine Reuptake Inhibitor

Darlene C. Deecher, Chad E. Beyer, Grace H. Johnston, +4

Journal of Pharmacology and Experimental Therapeutics

Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction

Kimberly J. Sipe, Liza Leventhal, Kevin D. Burroughs, +3

Brain Research

Endocrine MechanismMedicineHormonal ReceptorPhysiologyRodent Models +6

Alleviation of Thermoregulatory Dysfunction with the New Serotonin and Norepinephrine Reuptake Inhibitor Desvenlafaxine Succinate in Ovariectomized Rodent Models

Darlene C. Deecher, Peter D. Alfinito, Liza Leventhal, +4

Endocrinology

Dual acting norepinephrine reuptake inhibitors and 5-HT2A receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles

Gavin D. Heffernan, Richard D. Coghlan, Eric S. Manas, +14

Bioorganic & Medicinal Chemistry

MedicineDrug DiscoveryMechanism Of Action5-Ht2a Receptor AntagonistsPharmacological Agent +4

1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as Potent and Selective Norepinephrine Reuptake Inhibitors

A. T. Vu, Stephen T. Cohn, Puwen Zhang, +13

Journal of Medicinal Chemistry

Dopamine TransportersMedicinal ChemistrySelective NriBiochemistryFunctional Selectivity +9

Structure−Activity Relationships of the Cycloalkanol Ethylamine Scaffold: Discovery of Selective Norepinephrine Reuptake Inhibitors

Paige E. Mahaney, Lori K. Gavrin, Eugene J. Trybulski, +21

Journal of Medicinal Chemistry

Organic ChemistryPharmacotherapyExcellent SelectivityChemical BiologyPharmaceutical Chemistry +15

3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors

A. T. Vu, Stephen T. Cohn, Eugene A. Terefenko, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDual NorepinephrinePsychoactive DrugSerotonin Reuptake InhibitorsMedicine +7

Structure–activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors

Paige E. Mahaney, Callain Y. Kim, Richard D. Coghlan, +12

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicineMonoamine NeurotransmittersMonoamine Reuptake Inhibitors +5

Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors

Puwen Zhang, Eugene A. Terefenko, Casey C. McComas, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacological AgentOrganic Chemistry3-Amino-1-phenyl Propyl +4

Subchronic 17α-ethinyl estradiol differentially affects subtypes of sleep and wakefulness in ovariectomized rats

Aaron C. Pawlyk, Peter D. Alfinito, Grace H. Johnston, +1

Hormones and Behavior

SleepEndocrine MechanismComparative EndocrinologyPhysiologyNeuroendocrinology +6