Recombinant Acylation Stimulating Protein Administration to C3−/− Mice Increases Insulin Resistance via Adipocyte Inflammatory Mechanisms

Abstract

The effects of chronic rASP administration are tissue and diet specific, rASP administration enhances the HFD induced inflammatory response leading to an insulin-resistant state. These results suggest that, in humans, the increased plasma ASP associated with obesity and cardiovascular disease could be an additional factor directly contributing to development of metabolic syndrome, insulin resistance and diabetes.