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SAICAR Induces Protein Kinase Activity of PKM2 that Is Necessary for Sustained Proliferative Signaling of Cancer Cells

Kirstie E. Keller, Zainab M. Doctor, Zachary W. Dwyer, Young‐Sam Lee

Molecular Cell · 2014 · 179 citations · 20 references

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References

20

Spectroscopic Determination of Tryptophan and Tyrosine in Proteins<sup>*</sup>

Harold Edelhoch · Biochemistry · 1967 · 3.5K citations

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris et al. · Nature · 2008 · 2.8K citations

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Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

Weibo Luo, Hongxia Hu, Ryan Chang et al. · Cell · 2011 · 1.4K citations · Full text

, , +16

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

Weiwei Yang, Yan Xia, Haitao Ji et al. · Nature · 2011 · 1K citations · Full text

, , +7

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

Weiwei Yang, Yanhua Zheng, Yan Xia et al. · Nature Cell Biology · 2012 · 915 citations · Full text

, , +16