Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824

A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

C. Kendall Stover, Paul Warrener, Donald R. VanDevanter et al. · Nature · 2000 · 1K citations

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OPC-67683, a Nitro-Dihydro-Imidazooxazole Derivative with Promising Action against Tuberculosis In Vitro and In Mice

Makoto Matsumoto, Hiroyuki Hashizume, Tatsuo Tomishige et al. · PLoS Medicine · 2006 · 740 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in <i>Mycobacterium tuberculosis</i>

Ujjini H. Manjunatha, Helena I. Boshoff, Cynthia S. Dowd et al. · Proceedings of the National Academy of Sciences · 2005 · 332 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Preclinical Testing of the Nitroimidazopyran PA-824 for Activity against <i>Mycobacterium tuberculosis</i> in a Series of In Vitro and In Vivo Models

Anne J. Lenaerts, Veronica Gruppo, Karen S. Marietta et al. · Antimicrobial Agents and Chemotherapy · 2005 · 305 citations

Medicine, Infectious Diseases, Pharmacology +14

Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis

L G Wayne, H A Sramek · Antimicrobial Agents and Chemotherapy · 1994 · 299 citations · Full text

Life Sciences, Infectious Diseases, Microbiology +14