Systemic Administration of Simvastatin after the Onset of Experimental Subarachnoid Hemorrhage Attenuates Cerebral Vasospasm

Abstract

Subcutaneous administration of simvastatin after the onset of SAH attenuates perivascular granulocyte migration and ameliorates basilar artery vasospasm after experimental SAH in rabbits. 5-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, such as simvastatin, may potentially serve as agents in the prevention of cerebral vasospasm after SAH.