LRP2 Is an Auxiliary SHH Receptor Required to Condition the Forebrain Ventral Midline for Inductive Signals

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

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Patched1 Regulates Hedgehog Signaling at the Primary Cilium

Rajat Rohatgi, Ljiljana Milenković, Matthew P. Scott · Science · 2007 · 1.5K citations

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Jussi Taipale, James Chen, Michael K. Cooper et al. · Nature · 2000 · 1.3K citations

Medicine, Cancer Biology, Oncology +9

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

Henk Roelink, Adela Augsburger, Jill Heemskerk et al. · Cell · 1994 · 868 citations

Life Sciences, Biology, Developmental Biology +16

A binding site for Gli proteins is essential for <i>HNF-3</i>β floor plate enhancer activity in transgenics and can respond to Shh in vitro

Hiroshi Sasaki, Chi-chung Hui, Masato Nakafuku et al. · Development · 1997 · 677 citations

Life Sciences, Developmental Biology, Genetics +16