Angiotensin-converting enzyme 2 protects from severe acute lung failure

Yumiko Imai, Keiji Kuba, Shuan Rao, +14

Nature

InflammationAcute Lung InjuryPulmonary Arterial HypertensionInflammatory Lung DiseaseLung Inflammation +5

<i>FTO</i> Obesity Variant Circuitry and Adipocyte Browning in Humans

Melina Claussnitzer, Simon N. Dankel, Kyoung-Han Kim, +16

New England Journal of Medicine

Obesity-associated variants within FTO form long-range functional connections with IRX3

Scott Smemo, Juan J. Tena, Kyoung-Han Kim, +22

Nature

ObesityMetabolic SyndromeEnergy HomeostasisSignal TransductionMolecular Physiology +10

Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling

Hiroshi Sasaki, Yuriko Nishizaki, Chi-chung Hui, +2

Development

Molecular RegulationSonic HedgehogTranscriptional RegulationSignaling PathwayCell Regulation +16

A binding site for Gli proteins is essential for <i>HNF-3</i>β floor plate enhancer activity in transgenics and can respond to Shh in vitro

Hiroshi Sasaki, Chi-chung Hui, Masato Nakafuku, +1

Development

GeneticsSonic HedgehogTranscriptional RegulationSignaling PathwayCell Regulation +16

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in <i>Gli2</i> mutant mice

Qi Ding, Jun Motoyama, Stéphan Gasca, +4

Development

Basal cell carcinomas in mice overexpressing Gli2 in skin

Marina Grachtchouk, Rong Mo, Sandy Yu, +4

Nature Genetics

Cutaneous BiologyDermatologyMedicineCancer ResearchTumor Biology +2

Drosophila Genome-wide Obesity Screen Reveals Hedgehog as a Determinant of Brown versus White Adipose Cell Fate

J. Andrew Pospisilik, Daniel Schramek, Harald Schnidar, +23

Cell

ObesityMetabolic SyndromeBiologyCell LineageDevelopmental Biology +8

Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development

Pleasantine Mill, Rong Mo, Hong En Fu, +4

Genes & Development

Gli Transcription FactorsGeneticsCell ProliferationReproductive BiologyDermatology +15

Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development

Jun Takeuchi, Maria Mileikovskaia, Kazuko Koshiba‐Takeuchi, +13

Development