Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Shin‐ichiro Imai, Christopher M. Armstrong, Matt Kaeberlein et al. · Nature · 2000 · 3.5K citations

Histone Modifications, Chromatin, Transcriptional Regulation +12

Sequence and structure-based prediction of eukaryotic protein phosphorylation sites

Nikolaj Blom, Steen Gammeltoft, Søren Brunak · Journal of Molecular Biology · 1999 · 3.2K citations

Medicine, Natural Sciences, Molecular Biology +7

HDAC6 is a microtubule-associated deacetylase

Charlotte Hubbert, Amaris R. Guardiola, Rong Shao et al. · Nature · 2002 · 2.3K citations

Biochemistry, Natural Sciences, Microtubule-associated Deacetylase +4

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Matt Kaeberlein, Mitch McVey, Leonard Guarente · Genes & Development · 1999 · 2.3K citations · Full text

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Heidi A. Tissenbaum, Leonard Guarente · Nature · 2001 · 1.9K citations

Lifespan Extension, Developmental Biology, Longevity +9