AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

Masamichi Muramatsu, Kazuo Kinoshita, Sidonia Fagarasan et al. · Cell · 2000 · 3.4K citations

Natural Sciences, Genetics, Rna Biology +7

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

Emmy P. Rogakou, Chye Boon, Christophe E. Redon et al. · The Journal of Cell Biology · 1999 · 2.4K citations · Full text

Megabase Chromatin, Dna Damage, Genetics +22

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

Tanya T. Paull, Emmy P. Rogakou, Vikky Yamazaki et al. · Current Biology · 2000 · 2.1K citations · Full text

Histone Modifications, Dna Damage, Epigenetic Change +16

Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)

Patrick Revy, Taro Muto, Yves Lévy et al. · Cell · 2000 · 1.6K citations · Full text

Mendelian Disorder, Autoimmune Disease, Genetic Disorder +8

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

James P. Carney, Richard S. Maser, Heidi Olivares et al. · Cell · 1998 · 1.2K citations · Full text

Chromatin, Genome Instability, Double-strand Break Repair +11