Telomere dysfunction induces metabolic and mitochondrial compromise

Ergün Sahin, Simona Colla, Marc Liesa, +27

Nature

Mitochondrial FunctionGeneticsPhysiologyMetabolismMedicine +2

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

James P. Carney, Richard S. Maser, Heidi Olivares, +6

Cell

ChromatinGenome InstabilityDouble-strand Break RepairDna DamageHmre11/hrad50 Protein Complex +9

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

Grant S. Stewart, Richard S. Maser, Debra A. Bressan, +6

Cell

Genome InstabilityMendelian DisorderGenetic DisorderMedicineGenetics +9

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

Dae‐Sik Lim, Seong‐Tae Kim, Bo Xu, +3

Nature

Cell CycleTumor SuppressorS-phase Checkpoint PathwayMedicineCell Biology +2

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

Hiroyuki Inuzuka, Shavali Shaik, Ichiro Onoyama, +17

Nature

Signaling PathwayCell RegulationApoptosisImmunologyCellular Apoptosis +4

Telomere Shortening and Mood Disorders: Preliminary Support for a Chronic Stress Model of Accelerated Aging

Naomi M. Simon, Jordan W. Smoller, Kate L. McNamara, +6

Biological Psychiatry

AgingPsychiatryHealthy AgingLongevityGeriatrics +9

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

Richard S. Maser, Kirsten J. Monsen, Benjamin E. Nelms, +1

Molecular and Cellular Biology

Dna DamageNormal Cellular ResponseDsb Repair ProteinMolecular BiologyDsb Repair +14

In Situ Visualization of DNA Double-Strand Break Repair in Human Fibroblasts

Benjamin E. Nelms, Richard S. Maser, James F. MacKay, +2

Science

ChromatinGenome InstabilityFibrosisDna DamageCell Division +12

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Richard S. Maser, Bhudipa Choudhury, Peter J. Campbell, +33

Nature

ChromatinTumor BiologyGenome InstabilityGenomic AlterationsSomatic Variant +11

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

Kwok‐Kin Wong, Richard S. Maser, Robert Bachoo, +5

Nature

AgingLongevityGeneticsPhysiologyCellular Senescence +5