Concepedia

Class Switching Recombination

Class Switching Recombination is a genetic recombination process in B lymphocytes that changes the constant region of the antibody heavy chain, thereby altering the antibody isotype while preserving antigen specificity, as part of the adaptive immune response to parasites.

112

Publications

9.8K

Citations

499

Authors

172

Institutions

Publications per year

2017–2026

11

Variants

Isotype Switch Recombination

Parents

Publications

112

Class-Switch Recombination Occurs Infrequently in Germinal Centers

Jonathan A. Roco, Luka Mesin, Sebastian Binder et al. · Immunity · 2019 · 503 citations · Full text

, , +9

AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

Simone Petersen, Rafael Casellas, Bernardo Reina‐San‐Martin et al. · Nature · 2001 · 496 citations · Full text

, , +7

Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element

Steffen Jung, Klaus Rajewsky, Andreas Radbruch · Science · 1993 · 341 citations

, , +17

C-Terminal Deletion of AID Uncouples Class Switch Recombination from Somatic Hypermutation and Gene Conversion

Vasco M. Barreto, Bernardo Reina‐San‐Martin, Almudena R. Ramiro et al. · Molecular Cell · 2003 · 264 citations · Full text

, , +15

The AID enzyme induces class switch recombination in fibroblasts

Il‐mi Okazaki, Kazuo Kinoshita, Masamichi Muramatsu et al. · Nature · 2002 · 259 citations

, , +9

1–5 of 112

Authors

499

  1. JS
    Janet Stavnezer

    University of Massachusetts Chan Medical School, United States

    13 publications · 990 citations

    13

    h-index

  2. TH
    Tasuku Honjo

    Kyoto University, Japan

    14 publications · 1.8K citations

    12

    h-index

  3. MC
    Michel C. Nussenzweig

    Rockefeller University, United States

    8 publications · 1.3K citations

    8

    h-index

  4. AR
    Andreas Radbruch

    German Rheumatism Research Centre, Germany

    8 publications · 954 citations

    8

    h-index

  5. KK
    Kazuo Kinoshita

    Kyoto University, Japan

    7 publications · 768 citations

    7

    h-index

1–5 of 499

Institutions

172

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    13 h-index

    33 publications

    6.3K citations

  2. Kyoto University

    Kyoto, Japan

    13 h-index

    69 publications

    7.2K citations

  3. University of Massachusetts Chan Medical School

    Worcester, United States

    12 h-index

    35 publications

    2.7K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    31 publications

    2.8K citations

  5. Rockefeller University

    New York, United States

    7 h-index

    27 publications

    4.9K citations

  6. Harvard University

    Cambridge, United States

    5 h-index

    17 publications

    2.7K citations

  7. National Institutes of Health

    Bethesda, United States

    5 h-index

    20 publications

    5.3K citations

  8. Tufts University

    Medford, United States

    4 h-index

    5 publications

    578 citations

1–8 of 172

Venues

  1. The Journal of Immunology

    JI · 13 publications · 868 citations

    13

    h-index

  2. The Journal of Experimental Medicine

    10 publications · 972 citations

    10

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 9 publications · 763 citations

    9

    h-index

  4. Blood

    6 publications · 349 citations

    6

    h-index

  5. The EMBO Journal

    5 publications · 427 citations

    5

    h-index

1–5