Journal of Natural Products · 2009 · 78 citations · 20 references
PharmacyMedicinal ChemistryPharmacologyCancer PharmacologyDrug DiscoveryStructure-activity RelationshipsMarine Bioactive CompoundsMarine Drug DiscoveryMarine Natural ProductsMarine PharmacologyStructure-activity Relationship AnalysisAntiproliferative AgentsAntiproliferative Drug ActionBioactive Compounds From Marine SpongesBioactive Marine MetabolitesChemical Shift AnalysisMarine AlkaloidsMarine Sponge MetabolitesSponges As Drug Sources
A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid, named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including (1)H-(15)N HMBC NMR experiments, which provided complementary (15)N chemical shift information in support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lines.
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Antineoplastic agents. 257. Isolation and structure of spongistatin 1
George R. Pettit, Zbigniew A. Chicacz, Feng Gao et al. · The Journal of Organic Chemistry · 1993 · 259 citations