Andrew D. Mesecar

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

Laura Riva, Shuofeng Yuan, Xin Yin et al. · Nature · 2020 · 837 citations · Full text

Large-scale Compound Repurposing, Medicine, Antiviral Drug Development +5

The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating Activity

Naina Barretto, Dalia Jukneliene, Kiira Ratia et al. · Journal of Virology · 2005 · 604 citations · Full text

Viral Replication, Viral Pathogenesis, Pathology +16

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

Kiira Ratia, Scott D. Pegan, Jun Takayama et al. · Proceedings of the National Academy of Sciences · 2008 · 524 citations · Full text

Viral Replication, Molecular Biology, Antiviral Drug +17

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

Aimee L. Eggler, Guowen Liu, John M. Pezzuto et al. · Proceedings of the National Academy of Sciences · 2005 · 447 citations · Full text

The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate

Melissa S. Jurica, Andrew D. Mesecar, Patrick J. Heath et al. · Structure · 1998 · 433 citations · Full text