Concepedia

Knockdown of hypoxia-inducible factor-1α in breast carcinoma MCF-7 cells results in reduced tumor growth and increased sensitivity to methotrexate

Jing Li, Mingxia Shi, Ying Cao, Wensu Yuan, Tianxiang Pang, Bing-Zong Li, Zhao Sun, Lei Chen, Robert Chunhua Zhao

Biochemical and Biophysical Research Communications · 2006 · 66 citations · 33 references

DOI

Concepts

References

33

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

, , +17

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

, , +14

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Peter Carmeliet, Yuval Dor, Jean-Marc Herbert et al. · Nature · 1998 · 2.5K citations

, , +16

A novel method for real time quantitative RT-PCR.

U E Gibson, Chris Heid, P. Mickey Williams · Genome Research · 1996 · 2.1K citations · Full text

, , +16

Regulation of hypoxia-inducible factor 1α is mediated by an O <sub>2</sub> -dependent degradation domain via the ubiquitin-proteasome pathway

Eric Huang, Jie Gu, Maureen Schau et al. · Proceedings of the National Academy of Sciences · 1998 · 2.1K citations · Full text

, , +15