The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

Emmy P. Rogakou, Duane R. Pilch, Ann H. Orr et al. · Journal of Biological Chemistry · 1998 · 5.4K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Bilirubin Is an Antioxidant of Possible Physiological Importance

Roland Stocker, Yorihiro Yamamoto, Antony F. McDonagh et al. · Science · 1987 · 3.5K citations

Life Sciences, Biochemistry, Physiology +17

c-Myc-regulated microRNAs modulate E2F1 expression

Kathryn A. O’Donnell, Erik A. Wentzel, Karen Zeller et al. · Nature · 2005 · 2.6K citations

Life Sciences, Genetics, Molecular Biology +12

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

Leo E. Otterbein, Fritz H. Bach, Jawed Alam et al. · Nature Medicine · 2000 · 2.1K citations

Life Sciences, Biochemistry, Immunology +12

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

Deborah J. Good, Peter J. Polverini, Farzan Rastinejad et al. · Proceedings of the National Academy of Sciences · 1990 · 1.1K citations · Full text

Medicine, Molecular Biology, Oncology +13