Anticancer prodrugs of butyric acid and formaldehyde protect against doxorubicin-induced cardiotoxicity

Ada Rephaeli, S Waks-Yona, Abraham Nudelman, +5

British Journal of Cancer

The anticancer prodrugs of butyric acid AN-7 and AN-9, possess antiangiogenic properties

Diana Blank‐Porat, Tal Gruss-Fischer, Nataly Tarasenko, +3

Cancer Letters

Anticancer ProdrugsMedicinal ChemistryBioorganic ChemistryButyric Acid An-7Biochemistry +8

The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity

Nataly Tarasenko, Gania Kessler‐Icekson, P. Boer, +6

Investigational New Drugs

Oncogenic AgentMedicinePharmacologyAnticancer ActivityAnticancer Agents +7

<i>In vivo</i> and <i>in vitro</i> antitumor activity of butyroyloxymethyl‐diethyl phosphate (AN‐7), a histone deacetylase inhibitor, in human prostate cancer

Ada Rephaeli, Diana Blank‐Porat, Nataly Tarasenko, +6

International Journal of Cancer

Histone Deacetylase InhibitorPathologyCancer BiologyTumor BiologyHuman Prostate Cancer +16

Histone deacetylase inhibitors: the anticancer, antimetastatic and antiangiogenic activities of AN-7 are superior to those of the clinically tested AN-9 (Pivanex)

Nataly Tarasenko, Abraham Nudelman, Igor Tarasenko, +4

Clinical & Experimental Metastasis

Medicinal ChemistryMedicineHistone Deacetylase InhibitorsPathologyPharmacotherapy +5

The selectivty and anti-metastatic activity of oral bioavailable butyric acid prodrugs

Ada Rephaeli, Michal Entin‐Meer, Dikla Angel, +7

Investigational New Drugs

Medicinal ChemistryPharmaceutical ScienceBiochemistryAnti-metastatic ActivityMedicine +6

Disparate Impact of Butyroyloxymethyl Diethylphosphate (AN-7), a Histone Deacetylase Inhibitor, and Doxorubicin in Mice Bearing a Mammary Tumor

Nataly Tarasenko, Suzanne M. Cutts, Don R. Phillips, +4

PLoS ONE

Breast OncologyHistone Deacetylase InhibitorPathologyMre11 ExpressionCancer Biology +16

Novel Prodrugs of Tegafur that Display Improved Anticancer Activity and Antiangiogenic Properties

Dikla Engel, Abraham Nudelman, Nataly Tarasenko, +5

Journal of Medicinal Chemistry

Vitro MatrigelPharmaceutical ScienceChemoprevention StrategyImmunologyPharmacotherapy +18

A histone deacetylase inhibitory prodrug – Butyroyloxymethyl diethyl phosphate – Protects the heart and cardiomyocytes against ischemia injury

Gania Kessler‐Icekson, Edith Hochhauser, T. Sinai, +8

European Journal of Pharmaceutical Sciences

Molecular PhysiologyBiochemistryMedicineNatural SciencesLipid Peroxidation +5

A novel valproic acid prodrug as an anticancer agent that enhances doxorubicin anticancer activity and protects normal cells against its toxicity in vitro and in vivo

Nataly Tarasenko, Suzanne M. Cutts, Don R. Phillips, +5

Biochemical Pharmacology

Medicinal ChemistryDoxorubicin Anticancer ActivityAnticancer AgentMedicinePharmacological Agent +6