Concepedia

Critical off‐target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets

Sebastian Dütting, Julius F. Heidenreich, Deya Cherpokova, Ehsan Amin, Si-Cai Zhang, Mohammad Reza Ahmadian, Cord Brakebusch, Bernhard Nieswandt

Journal of Thrombosis and Haemostasis · 2015 · 111 citations · 33 references

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33

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

Yuan Gao, J. Bradley Dickerson, Fukun Guo et al. · Proceedings of the National Academy of Sciences · 2004 · 1.1K citations · Full text

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Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

Kazuko Haga, Andrew C. Kruse, Hidetsugu Asada et al. · Nature · 2012 · 795 citations · Full text

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Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

Shigeru Shibata, Miki Nagase, Shigetaka Yoshida et al. · Nature Medicine · 2008 · 448 citations

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Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo

Ralph Tiedt, Tibor Schomber, Hui Hao-Shen et al. · Blood · 2006 · 418 citations

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Specificity and Mechanism of Action of EHT 1864, a Novel Small Molecule Inhibitor of Rac Family Small GTPases

Adam Shutes, Cercina Onesto, Virginie Picard et al. · Journal of Biological Chemistry · 2007 · 340 citations · Full text

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