Adam Shutes - Concepedia

Concepedia

Author

Adam Shutes

University of North Carolina at Chapel Hill

Also Known As

A. Shutes, Adam Shutes, Cox, Adrienne, Cox, Adrienne D., Juliano, Rudolph L., Schweighoffer, Fabien

39

Publications

1.8K

Citations

17

H-Index

38

Concepts

All Affiliations

University of North Carolina at Chapel Hill Blueprint Medicines (United States)Ono Pharmaceutical (United States)Merck Serono (Italy)Merck (Germany)

AS

About

Adam Shutes is an author at University of North Carolina at Chapel Hill specializing in medicine, molecular biology, and drug discovery.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	9	9	881
2	Natural Sciences	4	4	623
3	Biochemistry	4	4	190
4	Biomolecular Engineering	2	2	101
5	Cell Biology	2	2	416

Adam Shutes

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18

Publications

1.8K

Citations

16

H-Index

	Year	Citations
Specificity and Mechanism of Action of EHT 1864, a Novel Small Molecule Inhibitor of Rac Family Small GTPases Adam Shutes, Cercina Onesto, Virginie Picard, Journal of Biological Chemistry Molecular BiologyTumor BiologyMolecular PharmacologySignaling PathwayReceptor Tyrosine Kinase	2007	336
First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway Margit Hagel, Chandra Miduturu, Michael P. Sheets, Cancer Discovery	2015	305
A precision therapy against cancers driven by <i>KIT/PDGFRA</i> mutations Erica N Evans, Alexandra K. Gardino, Joseph L. Kim, Science Translational Medicine	2017	209
The p85 Subunit of Phosphatidylinositol 3-Kinase Associates with the Fc Receptor γ-Chain and Linker for Activitor of T Cells (LAT) in Platelets Stimulated by Collagen and Convulxin Jonathan M. Gibbins, Stephen J. Briddon, Adam Shutes, Journal of Biological Chemistry	1998	145
Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases Richard D. Caldwell, Hui Qiu, Ben Askew, Journal of Medicinal Chemistry Novel TherapyMedicineTyrosine KinaseHighly SelectiveImmunology	2019	136
DLC‐1 suppresses non‐small cell lung cancer growth and invasion by RhoGAP‐dependent and independent mechanisms Kevin D. Healy, Louis Hodgson, Tai Young Kim, Molecular Carcinogenesis	2007	132
Characterization of EHT 1864, a Novel Small Molecule Inhibitor of Rac Family Small GTPases Cercina Onesto, Adam Shutes, Virginie Picard, Methods in enzymology on CD-ROM/Methods in enzymology Molecular PharmacologyDrug TargetingSignal TransductionG Protein-coupled ReceptorMedicine	2008	128
Transforming Activity of the Rho Family GTPase, Wrch-1, a Wnt-regulated Cdc42 Homolog, Is Dependent on a Novel Carboxyl-terminal Palmitoylation Motif Anastacia C. Berzat, Janice E. Buss, Emily J. Chenette, Journal of Biological Chemistry Wrch-1 Membrane LocalizationMolecular BiologyCell GrowthCellular PhysiologyWnt-regulated Cdc42 Homolog	2005	80
Atypical Mechanism of Regulation of the Wrch-1 Rho Family Small GTPase Adam Shutes, Anastacia C. Berzat, Adrienne D. Cox, Current Biology Protein FunctionSignal TransductionAtypical MechanismBiochemistrySignaling Pathway	2004	79
Allosteric IGF-1R Inhibitors Timo Heinrich, Ulrich Grädler, Henning Böttcher, ACS Medicinal Chemistry Letters Molecular DockingMolecular PharmacologyDrug TargetAllosteric Igf-1r InhibitorsBiochemistry	2010	49

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