Asymmetric total synthesis of Tofacitinib

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

Paul S. Changelian, Mark E. Flanagan, Douglas J. Ball et al. · Science · 2003 · 670 citations · Full text

Medicine, Immunology, Pharmacology +17

Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3<i>R</i>,4<i>R</i>)-4-methyl-3-(methyl(7H-pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)

Jian‐kang Jiang, Kamran Ghoreschi, Francesca Deflorian et al. · Journal of Medicinal Chemistry · 2008 · 125 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors

Janusz J. Kulagowski, Wade Blair, Richard J. Bull et al. · Journal of Medicinal Chemistry · 2012 · 94 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Selective Removal of the Tert-Butoxycarbonyl Group from Secondary Amines: ZnBr₂as the Deprotecting Reagent

Satish C. Nigama, André Mann, Maurizio Taddei et al. · Synthetic Communications · 1989 · 64 citations

Natural Sciences, Chemistry, Organic Chemistry +6

Chirospecific Synthesis of (<i>S</i>)-(+)- and (<i>R</i>)-(-)-5-Amino-4-hydroxypentanoic Acid from L- and D-Glutamic Acid via (<i>S</i>)-(+)- and (<i>R</i>)-(-)-5-Hydroxy-2-oxopiperidine

Claus Herdeis · Synthesis · 1986 · 52 citations

Natural Sciences, Chemistry, Pharmacology +4