Concepedia

Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches

Agnese Chiara Pippione, Franco Dosio, Alex Ducime, Antonella Federico, Katia Martina, Stefano Sainas, Bente Frølund, Major Gooyit, Kim D. Janda, Donatella Boschi,

MedChemComm · 2015 · 47 citations · 14 references

Open access

Abstract

The hydroxytriazole system is here analysed and used to modulate acidic moieties present in lead compounds.

References

14

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

Nicholas A. Meanwell · Journal of Medicinal Chemistry · 2011 · 2.8K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Studies on v-triazoles. Part 4. The 4-methoxybenzyl group, a versatile N-protecting group for the synthesis of N-unsubstituted v-triazoles

Derek R. Buckle, C. J. M. ROCKELL · Journal of the Chemical Society Perkin Transactions 1 · 1982 · 151 citations

Pharmacy, Chemistry, Medicinal Chemistry +10

Syntheses and Conformational Analyses of Glutamate Analogs: 2-(2-Carboxy-3-substituted-cyclopropyl)glycines as Useful Probes for Excitatory Amino Acid Receptors

Keiko Shimamoto, Yasufumi Ohfune · Journal of Medicinal Chemistry · 1996 · 111 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

Repositioning of an existing drug for the neglected tropical disease Onchocerciasis

Christian Johannes Gloeckner, Amanda L. Garner, Fana B. Mersha et al. · Proceedings of the National Academy of Sciences · 2010 · 106 citations · Full text

Veterinary Medicine, Infectious Diseases, Veterinary Parasitology +17

Bioisosteres and Scaffold Hopping in Medicinal Chemistry

Nathan Brown · Molecular Informatics · 2014 · 81 citations

Pharmacy, Medicinal Chemistry, Bioisosterism +15