Minocycline delayed photoreceptor death in rds mice through iNOS-dependent mechanism.

Abstract

NO played a major role in the initial photoreceptor apoptosis in rds mice. The migration of activated microglia to the ONL contributed to the subsequent photoreceptor cell death; minocycline treatment ameliorated the photoreceptor apoptosis in rds mice, and this protective effect was partly through iNOS-suppressive mechanism.

References

Page 1

	Year	Citations
Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease Du Chu Wu, Vernice Jackson‐Lewis, Miquel Vila, Journal of Neuroscience Neurodegenerative DiseasesNigrostriatal Dopaminergic NeuronsNigrostriatal Dopaminergic PathwayMedicineParkinson Disease	2002	1.2K
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice Shan Zhu, Irina G. Stavrovskaya, Martin Drozda, Nature Neurodegenerative DiseasesAmyotrophic Lateral SclerosisMedicineNeuropharmacologyCytochrome C Release	2002	1.1K
Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease Minghua Chen, Victor Ona, Mingwei Li, Nature Medicine Delays MortalityCell DeathDegenerative DiseaseHuntington DiseaseNeuroprotection	2000	1K
A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window Juha Yrjänheikki, Tiina Tikka, Riitta Keinänen, Proceedings of the National Academy of Sciences Cerebrovascular DiseasePharmacotherapyFocal Cerebral IschemiaMinocycline ProtectsCerebral Vascular Regulation	1999	1K
Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. Cheryl Lyons, Gregory Orloff, James M. Cunningham Journal of Biological Chemistry	1992	870
Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. Paul Ponath, Suofu Qin, D J Ringler, Journal of Clinical Investigation Mouse EotaxinLaboratory ImmunologyImmunologyHuman Eosinophil ChemoattractantSelective Recruitment	1996	708
Apoptosis: Final common pathway of photoreceptor death in rd, rds, and mutant mice Guo‐Qing Chang, Ying Hao, Fulton Wong Neuron Mutant MicePhotoreceptor CellSignal TransductionFinal Common PathwayApoptosis	1993	649
Minocycline Provides Neuroprotection Against <i>N</i>-Methyl-<scp>d</scp>-aspartate Neurotoxicity by Inhibiting Microglia Tiina Tikka, Jari Koıstınaho The Journal of Immunology	2001	527
Targeting leukocyte MMPs and transmigration Veronika Brundula, N. Barry Rewcastle, Luanne M. Metz, Brain	2002	413
Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism Chun C. Chao, Shuxian Hu, Wen S. Sheng, Glia	1996	273

Page 1