Juha Yrjänheikki

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

Juha Yrjänheikki, Tiina Tikka, Riitta Keinänen et al. · Proceedings of the National Academy of Sciences · 1999 · 1K citations · Full text

Cerebrovascular Disease, Pharmacotherapy, Focal Cerebral Ischemia +23

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

Juha Yrjänheikki, Riitta Keinänen, M. Pellikka et al. · Proceedings of the National Academy of Sciences · 1998 · 992 citations

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease

Taneli Heikkinen, Kimmo Lehtimäki, Nina Vartiainen et al. · PLoS ONE · 2012 · 323 citations · Full text

Genetics, Disease Gene Identification, Mri Brain Volumetry +16

Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through <i>N</i> -methyl- <scp>d</scp> -aspartic acid-receptors and phospholipase A ₂

Susanna Miettinen, Francesca R. Fusco, Juha Yrjänheikki et al. · Proceedings of the National Academy of Sciences · 1997 · 286 citations

Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies

Diana W. Shineman, Guriqbal S. Basi, Jennifer L. Bizon et al. · Alzheimer s Research & Therapy · 2011 · 130 citations · Full text

Preclinical Therapeutics, Drug Target, Neurochemical Biomarkers +22