A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

Juha Yrjänheikki, Tiina Tikka, Riitta Keinänen, +3

Proceedings of the National Academy of Sciences

Cerebrovascular DiseasePharmacotherapyFocal Cerebral IschemiaMinocycline ProtectsCerebral Vascular Regulation +21

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

Juha Yrjänheikki, Riitta Keinänen, M. Pellikka, +2

Proceedings of the National Academy of Sciences

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease

Taneli Heikkinen, Kimmo Lehtimäki, Nina Vartiainen, +13

PLoS ONE

GeneticsDisease Gene IdentificationMri Brain VolumetryBehavioral PhenotypeHuntingtin Gene +14

Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through <i>N</i> -methyl- <scp>d</scp> -aspartic acid-receptors and phospholipase A ₂

Susanna Miettinen, Francesca R. Fusco, Juha Yrjänheikki, +6

Proceedings of the National Academy of Sciences

Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies

Diana W. Shineman, Guriqbal S. Basi, Jennifer L. Bizon, +15

Alzheimer s Research & Therapy

Preclinical TherapeuticsDrug TargetNeurochemical BiomarkersAd Animal ModelsLaboratory Animal Study +20

Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa‐B in neurons and protects against brain ischaemia with a wide therapeutic time window

Antti Nurmi, Nina Vartiainen, Rea Pihlaja, +3

Journal of Neurochemistry

Spreading Depression–Induced Gene Expression Is Regulated by Plasma Glucose

Jari Koıstınaho, Sanna Pasonen, Juha Yrjänheikki, +1

Stroke

β-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or β-amyloid deposits

Tarja Malm, Michael Ort, Leena Tähtivaara, +17

Proceedings of the National Academy of Sciences

Abeta DepositsAge-dependent Learning DeficitsSocial SciencesNeuroinflammationAlzheimer's Disease +16

Long-term protective effect of atorvastatin in permanent focal cerebral ischemia

Juha Yrjänheikki, Jari Koıstınaho, Mikko I. Kettunen, +4

Brain Research

ThrombosisCerebral Vascular RegulationLong-term Protective EffectCardiovascular DiseaseIschemic Stroke +12

Cerebral Blood Volume Alterations in the Perilesional Areas in the Rat Brain after Traumatic Brain Injury—Comparison with Behavioral Outcome

Riikka Immonen, Taneli Heikkinen, Leena Tähtivaara, +8

Journal of Cerebral Blood Flow & Metabolism

Traumatic Brain InjuryBehavioral OutcomeTraumatic Brain Injury—comparisonBrain LesionNeurological Injury +19