Jari Koıstınaho

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

Juha Yrjänheikki, Tiina Tikka, Riitta Keinänen et al. · Proceedings of the National Academy of Sciences · 1999 · 1K citations · Full text

Cerebrovascular Disease, Pharmacotherapy, Focal Cerebral Ischemia +23

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

Juha Yrjänheikki, Riitta Keinänen, M. Pellikka et al. · Proceedings of the National Academy of Sciences · 1998 · 992 citations

Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia

Tiina Tikka, Bernd L. Fiebich, Gundars Goldsteins et al. · Journal of Neuroscience · 2001 · 947 citations · Full text

P38 Mapk, Pharmacotherapy, Oxidative Stress +18

Minocycline Provides Neuroprotection Against <i>N</i>-Methyl-<scp>d</scp>-aspartate Neurotoxicity by Inhibiting Microglia

Tiina Tikka, Jari Koıstınaho · The Journal of Immunology · 2001 · 527 citations · Full text

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

Minna Oksanen, Andrew J. Petersen, Nikolay Naumenko et al. · Stem Cell Reports · 2017 · 327 citations · Full text