Secreted Factor R‐Spondin 2 is Involved in Refinement of Patterning of the Mammalian Cochlea

Abstract

Rspo2 is required to limit the number of outer hair cells to three rows and for optimal arrangement of peripheral nerve fibers. The Rspo2 gain- and loss-of-function studies show that in the ear, Rspo2 function is not consistent with its assigned role as a Wnt potentiator.