Concepedia

Loss-of-function Models

Loss-Of-Function Models is a type of transgenic organism in which a specific gene is inactivated or disrupted to elucidate its biological function by observing the resulting phenotypic consequences.

524

Publications

46.5K

Citations

3.7K

Authors

990

Institutions

Publications per year

2017–2026

181

Variants

Loss-of-function Organisms

Parents

Publications

524

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

Thijn R. Brummelkamp, René Bernards, Reuven Agami · Science · 2002 · 4.3K citations · Full text

, , +16

Infectious Diseases of the Fetus and Newborn Infant

Jack S. Remington, J. O. Klein · The Pediatric Infectious Disease Journal · 1984 · 2.5K citations

, , +17

Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in <i>Drosophila</i>

Fillip Port, Hui-Min Chen, Tzumin Lee et al. · Proceedings of the National Academy of Sciences · 2014 · 1.2K citations · Full text

, , +15

Notch signaling controls multiple steps of pancreatic differentiation

L. Charles Murtaugh, Ben Z. Stanger, Kristen M. Kwan et al. · Proceedings of the National Academy of Sciences · 2003 · 788 citations · Full text

, , +17

Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions

Femke Simmer, Celine Moorman, Alexander M. van der Linden et al. · PLoS Biology · 2003 · 650 citations · Full text

, , +10

1–5 of 524

Authors

3.7K

  1. NP
    Norbert Perrimon

    Harvard University, United States

    6 publications · 872 citations

    6

    h-index

  2. EC
    Eric C. Lai

    Kettering University, United States

    4 publications · 302 citations

    4

    h-index

  3. NI
    Neil I. Bower

    The University of Queensland, Australia

    3 publications · 258 citations

    3

    h-index

  4. HL
    Hongliang Li

    Wuhan University, China

    3 publications · 146 citations

    3

    h-index

  5. BM
    Benjamin M. Hogan

    The University of Queensland, Australia

    3 publications · 258 citations

    3

    h-index

1–5 of 3.7K

Institutions

990

  1. Harvard University

    Cambridge, United States

    31 h-index

    140 publications

    19.3K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    26 h-index

    83 publications

    18.4K citations

  3. Inserm

    Paris, France

    17 h-index

    79 publications

    4.3K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    16 h-index

    72 publications

    3.3K citations

  5. Baylor College of Medicine

    Houston, United States

    14 h-index

    77 publications

    8.3K citations

  6. University of Pennsylvania

    Philadelphia, United States

    14 h-index

    53 publications

    5.6K citations

  7. Johns Hopkins University

    Baltimore, United States

    12 h-index

    51 publications

    2.5K citations

  8. Washington University in St. Louis

    St Louis, United States

    11 h-index

    42 publications

    3K citations

1–8 of 990

Venues

  1. Development

    42 publications · 4.1K citations

    30

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 25 publications · 4.7K citations

    23

    h-index

  3. PLoS ONE

    20 publications · 991 citations

    16

    h-index

  4. Journal of Neuroscience

    13 publications · 984 citations

    13

    h-index

  5. Scientific Reports

    12 publications · 458 citations

    12

    h-index

1–5