Concepedia

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

Julie A. Moreno, Helois Radford, Diego Peretti, Joern R. Steinert, Nicholas Verity, Maria Guerra Martin, Mark Halliday, Jason Morgan, David Dinsdale, Catherine A. Ortori,

Nature · 2012 · 614 citations · 30 references

DOIFull text

Open access

Concepts

References

30

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

Heather P. Harding, Isabel Novoa, Yuhong Zhang et al. · Molecular Cell · 2000 · 3.2K citations · Full text

, , +12

Mice devoid of PrP are resistant to scrapie

Hansruedi Büeler, Adriano Aguzzi, Andreas W. Sailer et al. · Cell · 1993 · 2.1K citations · Full text

, , +8

A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

Michael Boyce, Kevin F. Bryant, Céline Jousse et al. · Science · 2005 · 1.4K citations

, , +15

Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis

Giovanna R. Mallucci, Andrew Dickinson, Jacqueline M. Linehan et al. · Science · 2003 · 760 citations

, , +17

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

Jeroen J.M. Hoozemans, Elise S. van Haastert, Diana A.T. Nijholt et al. · American Journal Of Pathology · 2009 · 592 citations · Full text

, , +16