Sustained translational repression by eIF2α-P mediates prion neurodegeneration

Julie A. Moreno, Helois Radford, Diego Peretti, +13

Nature

Neurodegenerative DiseasesTranscriptional RegulationMolecular NeuroscienceDegenerative PathologyTranslational Repression +6

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

Julie A. Moreno, Mark Halliday, Colin Molloy, +8

Science Translational Medicine

Creutzfeldt-jakob DiseaseImmunologyCell DeathSocial SciencesPrion Replication +16

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

M.S. Halliday, Helois Radford, Yusuke Sekine, +10

Cell Death and Disease

Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice

Mark Halliday, Helois Radford, Karlijn A. M. Zents, +8

Brain

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia

Helois Radford, Julie A. Moreno, Nicholas Verity, +2

Acta Neuropathologica

Neurochemical BiomarkersSynaptic SignalingProtein SynthesisAlzheimer's DiseaseDegenerative Pathology +21

RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration

Diego Peretti, Amandine Bastide, Helois Radford, +9

Nature

Age-Dependent Susceptibility to Manganese-Induced Neurological Dysfunction

Julie A. Moreno, Elizabeth C. Yeomans, Karin M. Streifel, +3

Toxicological Sciences

Neurodegenerative DiseasesJuvenile MiceBehavioral NeurosciencePhysiologyMn Exposure +13

Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice

Jifeng Bian, Jeffrey R. Christiansen, Julie A. Moreno, +5

Proceedings of the National Academy of Sciences

Creutzfeldt-jakob DiseaseResidue 226GeneticsMolecular BiologyNeurochemical Biomarkers +18

Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein

Jifeng Bian, Sehun Kim, Sarah J. Kane, +22

PLoS Pathogens

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

Sophie J. Bradley, Julie-Myrtille Bourgognon, Helen Sanger, +18

Journal of Clinical Investigation

Neurodegenerative DiseasesAlzheimer's DiseaseCholinergic TransmissionMedicineDementia +11