Applied and Environmental Microbiology · 1983 · 101 citations · 15 references
PharmacyPoultry ScienceToxicologyDevelopmental ToxicologyPoultry MedicineReproductive ToxicologyPoultry PharmacologyPoultry ToxicologyAlternaria MycotoxinsHistopathological ToxicitySublethal ToxicityTenuazonic AcidTeratogenic Exposure AssessmentToxicology Of Veterinary DrugsYolk Sac Development
The effects in the chicken embryo assay of four Alternaria metabolites (alternariol [AOH], alternariol methyl ether [AME], altenuene [ALT], and tenuazonic acid [TA]) were investigated. Administered to 7-day-old chicken embryos by yolk sac injection, AOH, AME, and ALT caused no mortality or teratogenic effect at doses up to 1,000, 500, and 1,000 micrograms per egg, respectively. TA exhibited a calculated 50% lethal dose of 548 micrograms per egg, with no teratogenic effect observed at either lethal or sublethal doses.
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Toxicity of metabolites produced by the "Alternaria".
R W Pero, H S Posner, Mathilde Blois et al. · Environmental Health Perspectives · 1973 · 154 citations · Full text