Inhibition of the organic anion‐transporting polypeptide 1B1 by quercetin: an<i>in vitro</i>and<i>in vivo</i>assessment

Abstract

These findings suggest that quercetin inhibits the OATP1B1-mediated transport of E3S and pravastatin in vitro and also has a modest inhibitory influence on the pharmacokinetics of pravastatin in healthy Chinese-Han male volunteers. The effects of quercetin on other OATP1B1 substrate drugs deserve further investigation.