Plasma Protein Binding of Challenging Compounds

Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery

J. Cory Kalvass, Tristan S. Maurer · Biopharmaceutics & Drug Disposition · 2002 · 415 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Appropriate calibration curve fitting in ligand binding assays

John W. A. Findlay, Robert F. Dillard · The AAPS Journal · 2007 · 371 citations · Full text

Medicine, Chemistry, Analytical Chemistry +11

Validation of a Rapid Equilibrium Dialysis Approach for the Measurement of Plasma Protein Binding

Nigel J. Waters, Rachel L. Jones, Gareth Williams et al. · Journal of Pharmaceutical Sciences · 2008 · 308 citations

Life Sciences, Biochemistry, Clinical Biochemistry +9

Central Nervous System Drug Disposition: The Relationship between in Situ Brain Permeability and Brain Free Fraction

Scott Summerfield, Kevin D. Read, David J. Begley et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 284 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

The Importance of Protein-Protein Interactions on the pH-Induced Conformational Changes of Bovine Serum Albumin: A Small-Angle X-Ray Scattering Study

Leandro R.S. Barbosa, María Grazia Ortore, Francesco Spinozzi et al. · Biophysical Journal · 2010 · 280 citations · Full text

Life Sciences, Biochemistry, Biophysics +15