Concepedia

Plasma Protein Binding Optimization

Plasma Protein Binding Optimization is a pharmacokinetic strategy that systematically modulates the extent to which a drug binds to plasma proteins to enhance its free fraction, thereby improving bioavailability, distribution, and therapeutic efficacy while minimizing potential toxicity.

26

Publications

1K

Citations

177

Authors

47

Institutions

Publications per year

2017–2026

7

Parents

Publications

26

Plasma Protein Binding of Challenging Compounds

Keith Riccardi, Shannon Cawley, Phillip D. Yates et al. · Journal of Pharmaceutical Sciences · 2015 · 117 citations

, , +12

3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 2. Lead Optimization

Paolo Pevarello, Maria Gabriella Brasca, Paolo Orsini et al. · Journal of Medicinal Chemistry · 2005 · 109 citations · Full text

, , +17

Effect of Plasma Protein Binding on Renal Clearance of Drugs

Gerhard Levy · Journal of Pharmaceutical Sciences · 1980 · 73 citations

, , +14

The Use of Pseudo-Equilibrium Constant Affords Improved QSAR Models of Human Plasma Protein Binding

Xiang‐Wei Zhu, Alexander Sedykh, Hao Zhu et al. · Pharmaceutical Research · 2013 · 65 citations · Full text

, , +12

Numerical Solution of Nonlinear Pharmacokinetic Equations: Effects of Plasma Protein Binding on Drug Distribution and Elimination

John J. Coffey, Francis J. Bullock, Paul T. Schoenemann · Journal of Pharmaceutical Sciences · 1971 · 58 citations

, , +17

1–5 of 26

Authors

177

  1. BJ
    Bobby J. Lucas

    United States Military Academy, United States

    1 publications · 36 citations

    1

    h-index

  2. CS
    Caitlyn Stromko

    Bristol-Myers Squibb (United States), United States

    1 publications · 54 citations

    1

    h-index

  3. JT
    J.P. Tillement

    Université Paris-Est Créteil, France

    1 publications · 21 citations

    1

    h-index

  4. YL
    Yu Li

    North China Electric Power University, China

    1 publications · 13 citations

    1

    h-index

  5. WD
    William D. Figg

    National Cancer Institute, United States

    1 publications · 38 citations

    1

    h-index

1–5 of 177

Institutions

47

  1. University at Buffalo, State University of New York

    Buffalo, United States

    2 h-index

    4 publications

    109 citations

  2. AstraZeneca (Sweden)

    Södertälje, Sweden

    1 h-index

    3 publications

    90 citations

  3. Collège de France

    Paris, France

    1 h-index

    2 publications

    38 citations

  4. Rutgers Sexual and Reproductive Health and Rights

    Utrecht, Netherlands

    1 h-index

    1 publications

    65 citations

  5. Anhui University of Traditional Chinese Medicine

    Hefei, China

    1 h-index

    3 publications

    36 citations

  6. Medical University of Vienna

    Vienna, Austria

    1 h-index

    5 publications

    125 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    1 h-index

    2 publications

    38 citations

  8. Charles River Laboratories (United Kingdom)

    Tranent, United Kingdom

    1 h-index

    4 publications

    96 citations

1–8 of 47

Venues

  1. Journal of Pharmaceutical Sciences

    6 publications · 364 citations

    6

    h-index

  2. Journal of Medicinal Chemistry

    3 publications · 164 citations

    3

    h-index

  3. International Journal of Biochemistry

    1 publications · 15 citations

    1

    h-index

  4. International Journal of Pharmaceutics

    1 publications · 53 citations

    1

    h-index

  5. 1

    h-index

1–5