Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

Xiao‐Jian Sun, Paul Rothenberg, C. Ronald Kahn et al. · Nature · 1991 · 1.6K citations

Life Sciences, Biochemistry, Molecular Biology +14

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

Hiroyuki Tamemoto, Takashi Kadowaki, Kazuyuki Tobe et al. · Nature · 1994 · 1.1K citations

Medicine, Biochemistry, Endocrinology +16

Role of IRS-2 in insulin and cytokine signalling

Xiao Jian Sun, Ling-Mei Wang, Yitao Zhang et al. · Nature · 1995 · 850 citations

Life Sciences, Endocrinology, Molecular Biology +12

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

Masayuki Otsu, I. Hiles, Ivan Gout et al. · Cell · 1991 · 784 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

Edward Y. Skolnik, Ben Margolis, Moosa Mohammadi et al. · Cell · 1991 · 644 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15