Concepedia

Phosphoinositide Phosphorylation

Phosphoinositide Phosphorylation is a biochemical process in which phosphate groups are covalently attached to the inositol ring of phosphatidylinositol lipids by specific lipid kinases, thereby generating distinct phosphoinositide species that serve as signaling molecules in cellular regulation.

3.4K

Publications

237.7K

Citations

11.2K

Authors

2K

Institutions

Publications per year

2017–2026

246

Parents

Publications

3.4K

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

Tomohiko Maehama, Jack E. Dixon · Journal of Biological Chemistry · 1998 · 3.1K citations · Full text

, , +17

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Dario R. Alessi, Stephen R. James, C. Peter Downes et al. · Current Biology · 1997 · 2.8K citations · Full text

, , +12

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

Tatsuya Tamaoki, Hisayo Nomoto, ISAMI TAKAHASHI et al. · Biochemical and Biophysical Research Communications · 1986 · 2.5K citations

, , +10

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

Michael J. Berridge, R. M. C. Dawson, C. Peter Downes et al. · Biochemical Journal · 1983 · 2K citations · Full text

, , +14

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Edward H. Walker, Michael E. Pacold, Olga Perišić et al. · Molecular Cell · 2000 · 1.2K citations · Full text

, , +14

1–5 of 3.4K

Authors

11.2K

  1. CP
    C. Peter Downes

    University of Dundee, United Kingdom

    41 publications · 9.7K citations

    29

    h-index

  2. TB
    Tamás Balla

    National Institutes of Health, United States

    30 publications · 3.8K citations

    26

    h-index

  3. LC
    Lewis C. Cantley

    Harvard University, United States

    28 publications · 5.8K citations

    25

    h-index

  4. LS
    Len Stephens

    Babraham Institute, United Kingdom

    25 publications · 4.2K citations

    23

    h-index

  5. PT
    Phillip T. Hawkins

    Babraham Institute, United Kingdom

    22 publications · 2.9K citations

    21

    h-index

1–5 of 11.2K

Institutions

2K

  1. National Institutes of Health

    Bethesda, United States

    57 h-index

    338 publications

    36.4K citations

  2. Harvard University

    Cambridge, United States

    48 h-index

    228 publications

    30.8K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    45 h-index

    171 publications

    18.8K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    40 h-index

    306 publications

    18.1K citations

  5. Inserm

    Paris, France

    39 h-index

    355 publications

    17.6K citations

  6. University of California San Diego

    San Diego, United States

    39 h-index

    194 publications

    26.3K citations

  7. University College London

    London, United Kingdom

    36 h-index

    137 publications

    13.7K citations

  8. University of Pennsylvania

    Philadelphia, United States

    35 h-index

    148 publications

    16.3K citations

1–8 of 2K

Venues

  1. Journal of Biological Chemistry

    JBC · 448 publications · 53.9K citations

    124

    h-index

  2. Biochemical Journal

    BJ · 189 publications · 15.7K citations

    64

    h-index

  3. Journal of Neurochemistry

    JNC · 134 publications · 7K citations

    49

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 60 publications · 8K citations

    48

    h-index

  5. FEBS Letters

    105 publications · 4.8K citations

    40

    h-index

1–5