Mechanism of apoptosis induced by a lysosomotropic agent, L-Leucyl-L-Leucine methyl ester

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Donald W. Nicholson, Ambereen Ali, Nancy A. Thornberry et al. · Nature · 1995 · 4K citations

Protein Function, Biochemistry, Ice/ced-3 Protease +11

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

Hideki Sakahira, Masato Enari, Shigekazu Nagata · Nature · 1998 · 1.6K citations

Apoptosis, Cell Death, Anti-cancer Agent +8

Programmed cell death during <i>Drosophila</i> embryogenesis

John Abrams, Kristin White, Liselotte I. Fessler et al. · Development · 1993 · 705 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

Santos A. Susín, Naoufal Zamzami, Maria Castedo et al. · The Journal of Experimental Medicine · 1997 · 622 citations · Full text

Uptake of Oxidized LDL by Macrophages Results in Partial Lysosomal Enzyme Inactivation and Relocation

Wei Li, Xi Yuan, Anders Olsson et al. · Arteriosclerosis Thrombosis and Vascular Biology · 1998 · 123 citations · Full text