Concepedia

Lysosomotropic Agents

Lysosomotropic Agents is a class of weakly basic compounds that selectively accumulate within lysosomes due to their ability to diffuse across membranes in an unprotonated form and become trapped upon protonation in the acidic lysosomal lumen, thereby modulating lysosomal function and autophagic flux.

616

Publications

48.9K

Citations

2.6K

Authors

745

Institutions

Publications per year

2017–2026

89

Parents

Publications

616

3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

Per O. Seglen, Paul B. Gordon · Proceedings of the National Academy of Sciences · 1982 · 1.3K citations · Full text

, , +15

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

G Carpenter, Stanley Cohen · The Journal of Cell Biology · 1976 · 1.3K citations · Full text

, , +10

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

Graham Simmons, Dhaval N. Gosalia, Andrew J. Rennekamp et al. · Proceedings of the National Academy of Sciences · 2005 · 1.1K citations · Full text

, , +17

A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles.

Shoshana Paglin, Timothy Hollister, Thomas Delohery et al. · PubMed · 2001 · 959 citations

, , +17

The Proton Sponge: a Trick to Enter Cells the Viruses Did Not Exploit

Jean‐Paul Behr · CHIMIA International Journal for Chemistry · 1997 · 921 citations · Full text

, , +17

1–5 of 616

Authors

2.6K

  1. RA
    Raymond A. Firestone

    Bristol-Myers Squibb (United States), United States

    9 publications · 710 citations

    9

    h-index

  2. UT
    Ulf T. Brunk

    Linköping University, Sweden

    8 publications · 1.3K citations

    8

    h-index

  3. PO
    Per O. Seglen

    Norwegian Cancer Society, Norway

    7 publications · 1.8K citations

    7

    h-index

  4. JŁ
    Jacek Łuczyński

    Wrocław University of Science and Technology, Poland

    7 publications · 152 citations

    7

    h-index

  5. PB
    Paul B. Gordon

    Norwegian Cancer Society, Norway

    5 publications · 1.6K citations

    5

    h-index

1–5 of 2.6K

Institutions

745

  1. Inserm

    Paris, France

    16 h-index

    81 publications

    3.6K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    43 publications

    2K citations

  3. Harvard University

    Cambridge, United States

    11 h-index

    23 publications

    3.1K citations

  4. University of Pennsylvania

    Philadelphia, United States

    10 h-index

    58 publications

    16K citations

  5. National Institutes of Health

    Bethesda, United States

    10 h-index

    36 publications

    2.8K citations

  6. The University of Texas Southwestern Medical Center

    Dallas, United States

    9 h-index

    19 publications

    1.8K citations

  7. University of Oslo

    Oslo, Norway

    8 h-index

    17 publications

    994 citations

  8. Linköping University

    Linköping, Sweden

    8 h-index

    29 publications

    4.6K citations

1–8 of 745

Venues

  1. Journal of Virology

    JVI · 37 publications · 3.3K citations

    32

    h-index

  2. Journal of Biological Chemistry

    JBC · 39 publications · 3.6K citations

    28

    h-index

  3. PubMed

    Repository · 40 publications · 2.5K citations

    24

    h-index

  4. The Journal of Immunology

    JI · 21 publications · 2.1K citations

    20

    h-index

  5. The Journal of Cell Biology

    JCB · 19 publications · 5.2K citations

    19

    h-index

1–5