Concepedia

Molecular Assessment of the Potential for Renal Drug Interactions between Tenofovir and HIV Protease Inhibitors

Tomáš Cihlář, Adrian S. Ray, Geneviève Laflamme, Jennifer E. Vela, L. Tong, Michael D. Fuller, Anupma Roy, Gerald Rhodes

Antiviral Therapy · 2007 · 91 citations · 13 references

DOI

Abstract

These data indicate a low potential of PIs to interfere with the active tubular secretion of TFV and to alter the clinical renal safety profile of TDF.

References

13

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

John D. Schuetz, Michele Connelly, Daxi Sun et al. · Nature Medicine · 1999 · 577 citations

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HIV-1 Protease Inhibitors Are Substrates for the<i>MDR</i>1 Multidrug Transporter

Caroline Lee, Michael M. Gottesman, Carol Cardarelli et al. · Biochemistry · 1998 · 481 citations

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Cytotoxicity of Antiviral Nucleotides Adefovir and Cidofovir Is Induced by the Expression of Human Renal Organic Anion Transporter 1

Edmund Ho, Deborah C. Lin, Dirk B. Mendel et al. · Journal of the American Society of Nephrology · 2000 · 353 citations

Mechanism of Active Renal Tubular Efflux of Tenofovir

Adrian S. Ray, Tomáš Cihlář, Kelly L. Robinson et al. · Antimicrobial Agents and Chemotherapy · 2006 · 324 citations · Full text

Functional Involvement of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in the Renal Elimination of the Antiviral Drugs Adefovir and Tenofovir

Tomoki Imaoka, Hiroyuki Kusuhara, Masashi Adachi et al. · Molecular Pharmacology · 2006 · 279 citations