Functional Involvement of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in the Renal Elimination of the Antiviral Drugs Adefovir and Tenofovir

Tomoki Imaoka, Hiroyuki Kusuhara, Masashi Adachi, +3

Molecular Pharmacology

A Species Difference in the Transport Activities of H2 Receptor Antagonists by Rat and Human Renal Organic Anion and Cation Transporters

Harunobu Tahara, Hiroyuki Kusuhara, Hitoshi Endou, +4

Journal of Pharmacology and Experimental Therapeutics

Edoxaban Transport via P-Glycoprotein Is a Key Factor for the Drug’s Disposition

Tsuyoshi Mikkaichi, Yasushi Yoshigae, Hiroshi Masumoto, +5

Drug Metabolism and Disposition

The Renal-Specific Transporter Mediates Facilitative Transport of Organic Anions at the Brush Border Membrane of Mouse Renal Tubules

Tomoki Imaoka, Hiroyuki Kusuhara, Satomi Adachi‐Akahane, +4

Journal of the American Society of Nephrology

Renal SecretionRenal InflammationCellular PhysiologyMembrane TransportSaturable Uptake +16

A Potent Blood–Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model

Yukino Machida, Makoto Nakagawa, Hironori Matsunaga, +18

Molecular Cancer Therapeutics

Microphysiological system modeling of ochratoxin A-associated nephrotoxicity

Tomoki Imaoka, Jade Yang, Lu Wang, +8

Toxicology

Renal FunctionKidney ResearchMedicinePhysiologyToxicology +4

An Improved Vascularized, Dual-Channel Microphysiological System Facilitates Modeling of Proximal Tubular Solute Secretion

Alenka Chapron, Brian D. Chapron, Dale W. Hailey, +7

ACS Pharmacology & Translational Science

Bridging the gap between in silico and in vivo by modeling opioid disposition in a kidney proximal tubule microphysiological system

Tomoki Imaoka, Weize Huang, Sara Shum, +7

Scientific Reports

Evaluation of the Usefulness of Breast Cancer Resistance Protein (BCRP) Knockout Mice and BCRP Inhibitor-Treated Monkeys to Estimate the Clinical Impact of BCRP Modulation on the Pharmacokinetics of BCRP Substrates

Tsuyoshi Karibe, Rie Hagihara-Nakagomi, Kōji Abe, +7

Pharmaceutical Research

Bcrp ModulationBcrp SubstratesOncologyHealth SciencesBreast Oncology +11

Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity

Toru Taniguchi, Hiroaki Inagaki, Daichi Baba, +12

ACS Medicinal Chemistry Letters