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Dual PI3K/mTOR inhibitor, XL765 (SAR245409), shows superior effects to sole PI3K [XL147 (SAR245408)] or mTOR [rapamycin] inhibition in prostate cancer cell models

Giovanni Luca Gravina, Luca Scarsella, Alessandro Colapietro, Ana Jitariuc, Flora Vitale, Francesco Marampon, Enrico Ricevuto, Claudio Festuccia

Tumor Biology · 2015 · 26 citations · 36 references

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References

36

Cancer Statistics, 2008

Ahmedin Jemal, Rebecca L. Siegel, Elizabeth Ward et al. · CA A Cancer Journal for Clinicians · 2008 · 10.2K citations · Full text

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

Pradip K. Majumder, Phillip G. Febbo, Rachel Bikoff et al. · Nature Medicine · 2004 · 956 citations

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Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.

Máirín E. McMenamin, Peggy Soung, S Perera et al. · PubMed · 1999 · 638 citations

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Molecular characterization of human prostate carcinoma cell lines

Adrie van Bokhoven, Marileila Varella‐Garcia, Christopher Korch et al. · The Prostate · 2003 · 632 citations

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Increased AKT Activity Contributes to Prostate Cancer Progression by Dramatically Accelerating Prostate Tumor Growth and Diminishing p27Kip1 Expression

Jeremy R. Graff, Bruce W. Konicek, Ann M. McNulty et al. · Journal of Biological Chemistry · 2000 · 380 citations · Full text

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