Concepedia

Variable Region Immunogenicity

Variable Region Immunogenicity is a phenomenon in which the variable domains of therapeutic antibodies elicit an adaptive immune response due to sequence- or structure-derived immunogenic features distinct from those arising in the constant regions.

19

Publications

1.4K

Citations

108

Authors

24

Institutions

Publications per year

2017–2026

2

Parents

Publications

19

Biophysical Properties of Human Antibody Variable Domains

Stefan Ewert, Thomas Huber, Annemarie Honegger et al. · Journal of Molecular Biology · 2002 · 330 citations

, , +14

The immunogenicity of chimeric antibodies.

M. Brüggemann, Greg Winter, Herman Waldmann et al. · The Journal of Experimental Medicine · 1989 · 176 citations · Full text

, , +16

A possible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand-binding properties

Eduardo A. Padlan · Molecular Immunology · 1991 · 170 citations

, , +16

Idiotype vaccination against murine B cell lymphoma. Humoral and cellular responses elicited by tumor-derived immunoglobulin M and its molecular subunits.

Michael J. Campbell, W L Carroll, S Kon et al. · The Journal of Immunology · 1987 · 115 citations

, , +17

The immunogenicity of the 7E3 murine monoclonal Fab antibody fragment variable region is dramatically reduced in humans by substitution of human for murine constant regions

David Knight, Carrie Wagner, Robert E. Jordan et al. · Molecular Immunology · 1995 · 95 citations

, , +7

1–5 of 19

Authors

108

  1. EA
    Eduardo A. Padlan

    National Institutes of Health, United States

    1 publications · 170 citations

    1

    h-index

  2. SF
    Steve Frey

    GlaxoSmithKline (United States), United States

    1 publications · 67 citations

    1

    h-index

  3. DN
    David N. Fass

    Mayo Clinic, United States

    1 publications · 95 citations

    1

    h-index

  4. KT
    K Thielemans

    Vrije Universiteit Brussel, Belgium

    1 publications · 115 citations

    1

    h-index

  5. RP
    Richard P. Morrison

    Montana State University, United States

    1 publications · 50 citations

    1

    h-index

1–5 of 108

Institutions

24

  1. National Institutes of Health

    Bethesda, United States

    2 h-index

    7 publications

    470 citations

  2. Center of Molecular Immunology (Cuba)

    Havana, Cuba

    1 h-index

    6 publications

    240 citations

  3. Mayo Clinic

    Rochester, United States

    1 h-index

    1 publications

    95 citations

  4. Rocky Mountain College

    Billings, United States

    1 h-index

    1 publications

    50 citations

  5. Princeton University

    Princeton, United States

    1 h-index

    4 publications

    76 citations

  6. McGill University

    Montreal, Canada

    1 h-index

    2 publications

    48 citations

  7. Walter and Eliza Hall Institute of Medical Research

    Melbourne, Australia

    1 h-index

    2 publications

    172 citations

  8. University of California, Los Angeles

    Los Angeles, United States

    1 h-index

    3 publications

    120 citations

1–8 of 24

Venues

  1. Molecular Immunology

    3 publications · 289 citations

    3

    h-index

  2. The Journal of Experimental Medicine

    2 publications · 195 citations

    2

    h-index

  3. Nature

    2 publications · 136 citations

    2

    h-index

  4. International Immunology

    1 publications · 29 citations

    1

    h-index

  5. Journal of Fish Diseases

    1 publications · 29 citations

    1

    h-index

1–5