A possible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand-binding properties

Continuous cultures of fused cells secreting antibody of predefined specificity

Georges Köhler, César Milstein · Nature · 1975 · 17.2K citations

Pharmacy, Cell Biology, Immunology +11

The protein data bank: A computer-based archival file for macromolecular structures

F. C. Bernstein, Thomas F. Koetzle, G. J. B. Williams et al. · Journal of Molecular Biology · 1977 · 8.6K citations

Life Sciences, Biochemistry, Bioinformatics +14

Sequences of proteins of immunological interest

Analytical Biochemistry · 1984 · 3.4K citations

Life Sciences, Immunology, Molecular Biology +10

Analytical molecular surface calculation

Michael L. Connolly · Journal of Applied Crystallography · 1983 · 2.5K citations

Natural Sciences, Biophysics, Chemistry +17

Reshaping human antibodies for therapy

Lutz Riechmann, Herman Waldmann, Greg Winter · Nature · 1988 · 1.6K citations

Pharmacy, Immunology, Pharmaceutical Biotechnology +12