Concepedia

Tissue Distribution Simulation

Tissue Distribution Simulation is a computational modeling approach that characterizes the spatial and temporal movement of pharmaceutical compounds across biological tissues in vivo, distinguishing itself from other pharmacokinetic simulations by explicitly representing organ- and tissue-specific physiological parameters to predict compound concentration profiles beyond the systemic circulation.

187

Publications

10.3K

Citations

816

Authors

351

Institutions

Publications per year

2017–2026

50

Parents

Publications

187

Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions

Trudy Rodgers, Malcolm Rowland · Journal of Pharmaceutical Sciences · 2006 · 940 citations

, , +11

Physiologically Based Pharmacokinetic Modeling 1: Predicting the Tissue Distribution of Moderate-to-Strong Bases

Trudy Rodgers, David E. Leahy, Malcolm Rowland · Journal of Pharmaceutical Sciences · 2005 · 774 citations

, , +13

Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs

Stefan S. De Buck, Vikash K. Sinha, Luca A. Fenu et al. · Drug Metabolism and Disposition · 2007 · 253 citations

, , +16

Modelling tissues in 3D: the next future of pharmaco-toxicology and food research?

Giovanna Mazzoleni, Diego Di Lorenzo, Nathalie Steimberg · Genes & Nutrition · 2008 · 247 citations · Full text

, , +11

Strut Position, Blood Flow, and Drug Deposition

Brinda Balakrishnan, Abraham R. Tzafriri, Philip Seifert et al. · Circulation · 2005 · 209 citations · Full text

, , +10

1–5 of 187

Authors

816

  1. ER
    Elazer R. Edelman

    Massachusetts Institute of Technology, United States

    5 publications · 465 citations

    5

    h-index

  2. MR
    Malcolm Rowland

    University of Manchester, United Kingdom

    5 publications · 1.8K citations

    5

    h-index

  3. SM
    Sean McGinty

    University of Glasgow, United Kingdom

    4 publications · 190 citations

    4

    h-index

  4. KK
    Kannan Krishnan

    Université de Montréal, Canada

    4 publications · 253 citations

    4

    h-index

  5. MS
    M. Soltani

    University of Waterloo, Canada

    4 publications · 145 citations

    4

    h-index

1–5 of 816

Institutions

351

  1. Research Triangle Park Foundation

    Durham, United States

    6 h-index

    22 publications

    1.6K citations

  2. Brigham and Women's Hospital

    Boston, United States

    5 h-index

    20 publications

    2.2K citations

  3. University of Manchester

    Manchester, United Kingdom

    5 h-index

    10 publications

    3.6K citations

  4. Université de Montréal

    Montreal, Canada

    5 h-index

    16 publications

    1.1K citations

  5. Environmental Protection Agency

    Washington, United States

    5 h-index

    12 publications

    738 citations

  6. Washington University in St. Louis

    St Louis, United States

    4 h-index

    4 publications

    201 citations

  7. Harvard University

    Cambridge, United States

    4 h-index

    8 publications

    496 citations

  8. K.N.Toosi University of Technology

    Tehran, Iran

    4 h-index

    13 publications

    550 citations

1–8 of 351

Venues

  1. Journal of Pharmaceutical Sciences

    9 publications · 2.1K citations

    8

    h-index

  2. Pharmaceutical Research

    6 publications · 174 citations

    6

    h-index

  3. PLoS ONE

    6 publications · 327 citations

    6

    h-index

  4. 5

    h-index

  5. Toxicology and Applied Pharmacology

    TAAP · 5 publications · 475 citations

    5

    h-index

1–5