Concepedia

Th1 Effector Function

Th1 Effector Function is a cellular immune response phenotype characterized by the secretion of interferon-γ and interleukin-2 to promote macrophage activation and intracellular pathogen clearance, distinguishing it from other T helper effector lineages by its specialized role in cell-mediated immunity.

1K

Publications

94.6K

Citations

6.1K

Authors

1.4K

Institutions

Publications per year

2017–2026

139

Parents

Publications

1K

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

Laurent Monney, Catherine A. Sabatos, Jason L. Gaglia et al. · Nature · 2002 · 1.6K citations

, , +16

Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major

Patricia A. Darrah, Dipti T. Patel, Paula Mello De Luca et al. · Nature Medicine · 2007 · 1.4K citations

, , +14

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

Thomas Krausgruber, Katrina Blazek, Tim Smallie et al. · Nature Immunology · 2011 · 1.3K citations · Full text

, , +14

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

Kiyoshi Takeda, Björn E. Clausen, Tsuneyasu Kaisho et al. · Immunity · 1999 · 1.2K citations · Full text

, , +16

Lipopolysaccharide-enhanced, Toll-like Receptor 4–dependent T Helper Cell Type 2 Responses to Inhaled Antigen

Stephanie C. Eisenbarth, Damani A. Piggott, James W. Huleatt et al. · The Journal of Experimental Medicine · 2002 · 1.2K citations · Full text

, , +16

1–5 of 1K

Authors

6.1K

  1. SA
    Shizuo Akira

    The University of Osaka, Japan

    8 publications · 3.2K citations

    8

    h-index

  2. AR
    Andreas Radbruch

    German Rheumatism Research Centre, Germany

    8 publications · 1.5K citations

    8

    h-index

  3. SR
    Sergio Romagnani

    University of Florence, Italy

    8 publications · 742 citations

    8

    h-index

  4. DJ
    Dragana Janković

    National Institute of Allergy and Infectious Diseases, United States

    7 publications · 1.3K citations

    7

    h-index

  5. ML
    Max Löhning

    German Rheumatism Research Centre, Germany

    7 publications · 1.5K citations

    7

    h-index

1–5 of 6.1K

Institutions

1.4K

  1. National Institutes of Health

    Bethesda, United States

    35 h-index

    173 publications

    33K citations

  2. Inserm

    Paris, France

    24 h-index

    115 publications

    11.2K citations

  3. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    22 h-index

    84 publications

    20.6K citations

  4. Yale University

    New Haven, United States

    21 h-index

    69 publications

    14.6K citations

  5. University of Pennsylvania

    Philadelphia, United States

    18 h-index

    60 publications

    4K citations

  6. Harvard University

    Cambridge, United States

    17 h-index

    86 publications

    23.3K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    14 h-index

    38 publications

    2.7K citations

  8. Washington University in St. Louis

    St Louis, United States

    14 h-index

    41 publications

    4.5K citations

1–8 of 1.4K

Venues

  1. The Journal of Immunology

    JI · 186 publications · 19.4K citations

    84

    h-index

  2. The Journal of Experimental Medicine

    35 publications · 10.1K citations

    34

    h-index

  3. European Journal of Immunology

    EJI · 39 publications · 3.7K citations

    30

    h-index

  4. PubMed

    Repository · 47 publications · 5K citations

    28

    h-index

  5. Infection and Immunity

    IAI · 23 publications · 1.5K citations

    20

    h-index

1–5