IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

Thomas Krausgruber, Katrina Blazek, Tim Smallie, +6

Nature Immunology

Pooled CRISPR screening with single-cell transcriptome readout

Paul Datlinger, André F. Rendeiro, Christian Schmidl, +7

Nature Methods

Off-target EffectGeneticsSingle-cell GenomicsGene EditingCrispr +5

The alarmin IL-33 promotes regulatory T-cell function in the intestine

Chris Schiering, Thomas Krausgruber, Agnieszka Chomka, +13

Nature

InflammationCytokineAutoimmune DiseaseMucosal ImmunologyT-regulatory Cell +7

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

Elizabeth C. Rosser, Christopher Piper, Diana E. Matei, +13

Cell Metabolism

ImmunologyRegulatory B CellsInflammatory ArthritisB CellInflammation +15

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

Ricardo J. Miragaia, Tomás Gomes, Agnieszka Chomka, +13

Immunity

Structural cells are key regulators of organ-specific immune responses

Thomas Krausgruber, Nikolaus Fortelny, Victoria Fife, +8

Nature

Structural CellsAdaptive Immune SystemInnate Immune SystemImmune RegulationImmunology +6

Ultra-high-throughput single-cell RNA sequencing and perturbation screening with combinatorial fluidic indexing

Paul Datlinger, André F. Rendeiro, Thorina Boenke, +4

Nature Methods

EngineeringGeneticsTranscriptomics TechnologyGenomicsHigh Throughput Sequencing +14

Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine

Oliver J. Harrison, Naren Srinivasan, Johanna Pott, +4

Mucosal Immunology

InflammationCytokineAutoimmune DiseaseMucosal ImmunologyTh17 Cell Differentiation +8

Single-cell transcriptomics combined with interstitial fluid proteomics defines cell type–specific immune regulation in atopic dermatitis

Thomas B. Rojahn, Vera Vorstandlechner, Thomas Krausgruber, +12

Journal of Allergy and Clinical Immunology

InflammationAtopic DermatitisImmune Cell DevelopmentMedicineImmunology +10

Chromatin accessibility profiling methods

Liesbeth Minnoye, Georgi K. Marinov, Thomas Krausgruber, +9

Nature Reviews Methods Primers

BioinformaticsChromatinChromatin RemodelingMedicineGenetics +9