IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

Thomas Krausgruber, Katrina Blazek, Tim Smallie, +6

Nature Immunology

IL-10 inhibits transcription elongation of the human <i>TNF</i> gene in primary macrophages

Tim Smallie, Giuseppe Ricchetti, Nicole J. Horwood, +3

The Journal of Experimental Medicine

Mycolactone Inhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism

Rachel E. Simmonds, Ferdinand Lali, Tim Smallie, +2

The Journal of Immunology

InflammationMycolactone PretreatmentCytokineMicrobial PathogensTlr Ligands +13

Expression of Constitutively Active STAT3 Can Replicate the Cytokine-suppressive Activity of Interleukin-10 in Human Primary Macrophages

Lynn Williams, Ushā Śarmā, Kate Willets, +3

Journal of Biological Chemistry

ImmunologyImmune RegulationImmunologic MechanismInnate ImmunityImmunotherapy +17

Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin

Tina Tang, Thomas Scambler, Tim Smallie, +5

Scientific Reports

Chemical inhibition of Src family kinases affects major LPS-activated pathways in primary human macrophages

Maria Smolinska, Nicole J. Horwood, Theresa H. Page, +2

Molecular Immunology

InflammationPrimary Human MacrophagesSignal TransductionSignaling PathwayCell Regulation +10

Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide

Tim Smallie, Ewan A. Ross, Alaina J. Ammit, +8

The Journal of Immunology

Dual-specificity Phosphatase 1Innate Immune SystemImmunologyImmune RegulationInnate Immunity +24

Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin

Ewan A. Ross, Tim Smallie, Qize Ding, +12

The Journal of Immunology

ImmunologyImmune RegulationImmunologic MechanismInnate ImmunityInflammation +16

Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages <i>In Vitro</i> yet Has Overwhelmingly Anti-Inflammatory Consequences <i>In Vivo</i>

John D. O’Neil, Ewan A. Ross, Michael Ridley, +9

Molecular and Cellular Biology