Concepedia

Tet Enzymes

TET Enzymes is a family of iron- and α-ketoglutarate-dependent dioxygenases that catalyze the iterative oxidation of 5-methylcytosine to 5-hydroxymethylcytosine and further to 5-formylcytosine and 5-carboxylcytosine in DNA, thereby initiating active DNA demethylation.

396

Publications

48.1K

Citations

2.6K

Authors

723

Institutions

Publications per year

2017–2026

182

Parents

Publications

396

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

Shinsuke Ito, Li Shen, Qing Dai et al. · Science · 2011 · 3.4K citations

, , +5

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

Yufei He, Bin-Zhong Li, Zheng Li et al. · Science · 2011 · 2.8K citations

, , +12

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Shinsuke Ito, Ana C. D’Alessio, Olena Taranova et al. · Nature · 2010 · 2.5K citations

, , +8

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

Junjie U. Guo, Yijing Su, Chun Zhong et al. · Cell · 2011 · 1.4K citations · Full text

, , +14

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

Myunggon Ko, Yun Huang, A. Jankowska et al. · Nature · 2010 · 1.3K citations

, , +16

1–5 of 396

Authors

2.6K

  1. AR
    Anjana Rao

    Harvard University, United States

    21 publications · 5.4K citations

    19

    h-index

  2. YH
    Yun Huang

    Texas A&M University, United States

    11 publications · 3.2K citations

    11

    h-index

  3. RM
    Rahul M. Kohli

    University of Pennsylvania, United States

    10 publications · 573 citations

    10

    h-index

  4. LA
    L. Aravind

    National Center for Biotechnology Information, United States

    9 publications · 2.5K citations

    9

    h-index

  5. YZ
    Yi Zhang

    Howard Hughes Medical Institute, United States

    9 publications · 7.3K citations

    9

    h-index

1–5 of 2.6K

Institutions

723

  1. Chinese Academy of Sciences

    Beijing, China

    27 h-index

    161 publications

    51.1K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    21 h-index

    69 publications

    38.5K citations

  3. Center for Excellence in Molecular Cell Science

    Shanghai, China

    18 h-index

    96 publications

    50.2K citations

  4. University of California San Diego

    San Diego, United States

    17 h-index

    31 publications

    5.8K citations

  5. Ludwig-Maximilians-Universität München

    Munich, Germany

    16 h-index

    101 publications

    11.6K citations

  6. La Jolla Institute for Immunology

    San Diego, United States

    16 h-index

    86 publications

    18.8K citations

  7. National Institutes of Health

    Bethesda, United States

    15 h-index

    33 publications

    4.7K citations

  8. Sanford Consortium for Regenerative Medicine

    La Jolla, United States

    15 h-index

    31 publications

    6.4K citations

1–8 of 723

Venues

  1. Nucleic Acids Research

    27 publications · 2.4K citations

    22

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 17 publications · 2.4K citations

    16

    h-index

  3. Cell Reports

    14 publications · 1.4K citations

    14

    h-index

  4. Journal of the American Chemical Society

    JACS · 13 publications · 1.5K citations

    13

    h-index

  5. Nature

    13 publications · 9K citations

    13

    h-index

1–5