Concepedia

T Cell-dependent Activation

T Cell-Dependent Activation is a B cell activation mechanism that requires cognate help from CD4+ T helper cells, typically involving antigen presentation via MHC class II and co-stimulatory signals, to initiate germinal center formation, somatic hypermutation, and class switch recombination.

498

Publications

35.3K

Citations

2.5K

Authors

602

Institutions

Publications per year

2017–2026

45

Parents

Publications

498

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

Hirokazu Matsushita, Matthew D. Vesely, Daniel C. Koboldt et al. · Nature · 2012 · 1.3K citations · Full text

, , +16

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

Peter S. Linsley, Philip M. Wallace, Jennifer Johnson et al. · Science · 1992 · 806 citations

, , +16

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

Jonathan Kaye, S Porcelli, J P Tite et al. · The Journal of Experimental Medicine · 1983 · 648 citations · Full text

, , +15

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

Karen S. Hathcock, Glória László, Howard B. Dickler et al. · Science · 1993 · 518 citations

, , +17

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.

H. Lin, Steven F. Bolling, Peter S. Linsley et al. · The Journal of Experimental Medicine · 1993 · 489 citations · Full text

, , +16

1–5 of 498

Authors

2.5K

  1. PE
    Peter E. Lipsky

    The University of Texas Southwestern Medical Center, United States

    6 publications · 531 citations

    6

    h-index

  2. PS
    Peter S. Linsley

    Bristol-Myers Squibb (United States), United States

    5 publications · 1.9K citations

    5

    h-index

  3. KR
    Klaus Rajewsky

    University of Cologne, Germany

    5 publications · 310 citations

    5

    h-index

  4. RJ
    Richard J. Hodes

    National Institutes of Health, United States

    5 publications · 623 citations

    5

    h-index

  5. PW
    Philip W. Askenase

    Yale University, United States

    5 publications · 361 citations

    5

    h-index

1–5 of 2.5K

Institutions

602

  1. National Institutes of Health

    Bethesda, United States

    19 h-index

    65 publications

    5K citations

  2. Harvard University

    Cambridge, United States

    13 h-index

    41 publications

    2.3K citations

  3. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    13 h-index

    35 publications

    2.3K citations

  4. Inserm

    Paris, France

    13 h-index

    60 publications

    3.9K citations

  5. National Cancer Institute

    Bethesda, United States

    12 h-index

    39 publications

    3.2K citations

  6. The University of Texas Southwestern Medical Center

    Dallas, United States

    11 h-index

    30 publications

    5.2K citations

  7. Walter and Eliza Hall Institute of Medical Research

    Melbourne, Australia

    10 h-index

    33 publications

    3.2K citations

  8. University of Pennsylvania

    Philadelphia, United States

    9 h-index

    33 publications

    2.1K citations

1–8 of 602

Venues

  1. The Journal of Immunology

    JI · 129 publications · 7.9K citations

    52

    h-index

  2. The Journal of Experimental Medicine

    41 publications · 5.7K citations

    34

    h-index

  3. PubMed

    Repository · 58 publications · 1.7K citations

    26

    h-index

  4. European Journal of Immunology

    EJI · 26 publications · 1.8K citations

    20

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 16 publications · 1.8K citations

    15

    h-index

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