Systems Medicine

Systems medicine is an interdisciplinary biomedical discipline that applies systems biology approaches through integration of multi-scale biological and clinical data to achieve translational objectives in personalized diagnosis, prognosis, and therapy.

270

Publications

16.6K

Citations

1.3K

Authors

691

Institutions

Publications per year

2017–2026

Parents

Systems Biology

Children

Biomarker DiscoveryClinical Systems BiologyDisease Mechanism ModelingDisease ModelingDisease Progression ModelingDrug Response ModelingHost-microbiome InteractionsMolecular Interaction NetworksNetwork AnalysisNetwork Medicine

Publications

270

Systems Biology and New Technologies Enable Predictive and Preventative Medicine

Leroy Hood, James R. Heath, Michael E. Phelps et al. · Science · 2004 · 1.1K citations

Life Sciences, Molecular Medicine, Systems Biology +17

A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory

Leroy Hood, Mauricio Flores · New Biotechnology · 2012 · 641 citations

Computing, Health Informatics, Preventive Medicine +5

P4 Medicine: How Systems Medicine Will Transform the Healthcare Sector and Society

Mauricio Flores, Gustavo Glusman, Kristin Brogaard et al. · Personalized Medicine · 2013 · 624 citations

Life Sciences, Molecular Medicine, Clinical Medicine +10

Systems biology and combination therapy in the quest for clinical efficacy

Jonathan B. Fitzgerald, Birgit Schoeberl, Ulrik B. Nielsen et al. · Nature Chemical Biology · 2006 · 583 citations

Life Sciences, Pharmacology, Systems Biology +16

The Limits of Reductionism in Medicine: Could Systems Biology Offer an Alternative?

Andrew C. Ahn, Muneesh Tewari, Chi-Sang Poon et al. · PLoS Medicine · 2006 · 510 citations · Full text

Life Sciences, Biology, Systems Biology +5

1–5 of 270

Authors

1.3K

LH
Leroy Hood
California Institute of Technology, United States
12 publications · 4K citations
12
h-index
CA
Charles Auffray
Centre National de la Recherche Scientifique, France
12 publications · 1.8K citations
11
h-index
JB
Jan Baumbach
University of Southern Denmark, Denmark
9 publications · 427 citations
8
h-index
OW
Olaf Wolkenhauer
University of Rostock, Germany
6 publications · 478 citations
6
h-index
PJ
Peter J. Sterk
University of Amsterdam, Netherlands
5 publications · 677 citations
5
h-index

1–5 of 1.3K

Institutions

691

1–8 of 691

Venues

Genome Medicine
9 publications · 1.4K citations
9
h-index
PubMed
Repository · 7 publications · 365 citations
7
h-index
Briefings in Bioinformatics
7 publications · 572 citations
7
h-index
Journal of Evaluation in Clinical Practice
6 publications · 228 citations
6
h-index
Evidence-based Complementary and Alternative Medicine
5 publications · 178 citations
5
h-index

1–5

See also Systems Medicine
Core Methods	Network Analysis Multiscale Modeling Machine Learning Deep Learning Disease Modeling Information Theory Statistical Inference Probabilistic Modeling Graph Theory Natural Language Processing Semantic Processing Data Assimilation Dempster - Shafer Theory Differential Equations Hierarchical Bayesian Estimation Kalman Filtering Patient-specific Models
Applications	Drug Discovery Patient Stratification Drug Repurposing Disease Risk Assessment
Data Sources	Metabolomics Proteomics Interactomics Medical Imaging Genomics Transcriptomics Electronic Health Records Pathology Reports Real-time Patient Tracking
Challenges	Data Integration Interoperability Model Parameterization Clinical Validation Studies Model Interpretability High-dimensional Pattern Discovery Overfitting Missing Data
Translational Pipeline	Biomarker Discovery Multiscale Modeling Network Analysis Translational Bioinformatics Data Integration Disease Modeling