Concepedia

Synthetic Lethality Mapping

Synthetic Lethality Mapping is a genetic interaction mapping method that identifies pairs of genes whose simultaneous inactivation results in cell death, whereas inactivation of either gene alone is non-lethal, thereby revealing functional redundancies and potential therapeutic targets in biological networks.

12

Publications

1.4K

Citations

177

Authors

42

Institutions

Publications per year

2017–2026

7

Parents

Publications

12

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

E. Robert McDonald, Antoine de Weck, Michael R. Schlabach et al. · Cell · 2017 · 701 citations · Full text

, , +17

Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality

Livnat Jerby‐Arnon, Nadja Pfetzer, Yedael Y. Waldman et al. · Cell · 2014 · 306 citations · Full text

, , +16

Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome

Phoebe C. R. Parrish, James D. Thomas, Austin M. Gabel et al. · Cell Reports · 2021 · 119 citations · Full text

, , +17

Mapping Genetically Compensatory Pathways from Synthetic Lethal Interactions in Yeast

Xiaotu Ma, Aaron M. Tarone, Wenyuan Li · PLoS ONE · 2008 · 50 citations · Full text

, , +17

Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities

Liang Chang, Nancy Yoobin Jung, Adel Atari et al. · Nature Genetics · 2023 · 43 citations

, , +13

1–5 of 12

Authors

177

  1. JZ
    Jie Zheng

    Nanyang Technological University, Singapore

    2 publications · 44 citations

    2

    h-index

  2. WR
    William R. Sellers

    Dana-Farber Cancer Institute, United States

    2 publications · 744 citations

    2

    h-index

  3. ER
    Eytan Ruppin

    Tel Aviv University, Israel

    2 publications · 327 citations

    2

    h-index

  4. XL
    Xuejuan Li

    Shaanxi Normal University, China

    2 publications · 44 citations

    2

    h-index

  5. SK
    Shital Kumar Mishra

    Genome Institute of Singapore, Singapore

    2 publications · 44 citations

    2

    h-index

1–5 of 177

Institutions

42

  1. Nanyang Technological University

    Singapore, Singapore

    2 h-index

    8 publications

    176 citations

  2. Broad Institute

    Cambridge, United States

    2 h-index

    18 publications

    1.3K citations

  3. Institute for Infocomm Research

    Singapore, Singapore

    2 h-index

    2 publications

    44 citations

  4. Genome Institute of Singapore

    Singapore, Singapore

    2 h-index

    2 publications

    44 citations

  5. Heidelberg University

    Heidelberg, Germany

    1 h-index

    1 publications

    35 citations

  6. EmergenTec (Austria)

    Vienna, Austria

    1 h-index

    4 publications

    68 citations

  7. AstraZeneca (United States)

    Wilmington, United States

    1 h-index

    2 publications

    58 citations

  8. Huazhong University of Science and Technology

    Wuhan, China

    1 h-index

    1 publications

    31 citations

1–8 of 42

Venues

  1. Cell

    2 publications · 1K citations

    2

    h-index

  2. PLoS ONE

    2 publications · 67 citations

    2

    h-index

  3. BioMed Research International

    1 publications · 27 citations

    1

    h-index

  4. Molecular Cancer

    1 publications · 35 citations

    1

    h-index

  5. Theranostics

    1 publications · 31 citations

    1

    h-index

1–5