Concepedia

Substrate Specificity Engineering

Substrate Specificity Engineering is a protein engineering strategy that involves the targeted modification of an enzyme's active site or binding region to alter its preference for particular substrates, thereby enhancing or redirecting catalytic activity toward desired chemical transformations.

61

Publications

3K

Citations

286

Authors

120

Institutions

Publications per year

2017–2026

18

Parents

Publications

61

Directed evolution of a fucosidase from a galactosidase by DNA shuffling and screening

Ji-Hu Zhang, Glenn Dawes, Willem P.C. Stemmer · Proceedings of the National Academy of Sciences · 1997 · 274 citations

, , +15

Lacticin 481: In Vitro Reconstitution of Lantibiotic Synthetase Activity

Lili Xie, Leah M. Miller, Champak Chatterjee et al. · Science · 2004 · 247 citations

, , +17

Single amino acid bionanozyme for environmental remediation

Pandeeswar Makam, Sharma S. R. K. C. Yamijala, Venkata Srinu Bhadram et al. · Nature Communications · 2022 · 191 citations · Full text

, , +17

Reengineering a Tryptophan Halogenase To Preferentially Chlorinate a Direct Alkaloid Precursor

Weslee S. Glenn, Ezekiel Nims, Sarah E. O’Connor · Journal of the American Chemical Society · 2011 · 120 citations

, , +17

Site-Specific Sequential Protein Labeling Catalyzed by a Single Recombinant Ligase

Fabian B. H. Rehm, Thibault J. Harmand, Kuok Yap et al. · Journal of the American Chemical Society · 2019 · 108 citations · Full text

, , +14

1–5 of 61

Authors

286

  1. HC
    Hongzhi Cao

    Shandong University, China

    2 publications · 83 citations

    2

    h-index

  2. WM
    Willem M. de Vos

    Wageningen University & Research, Netherlands

    2 publications · 111 citations

    2

    h-index

  3. TK
    Thijs Kaper

    Wageningen University & Research, Netherlands

    2 publications · 111 citations

    2

    h-index

  4. PK
    Paulina Kasperkiewicz

    Wrocław University of Science and Technology, Poland

    2 publications · 133 citations

    2

    h-index

  5. JV
    John van der Oost

    Wageningen University & Research, Netherlands

    2 publications · 111 citations

    2

    h-index

1–5 of 286

Institutions

120

  1. Chinese Academy of Sciences

    Beijing, China

    4 h-index

    9 publications

    311 citations

  2. Seoul National University

    Seoul, South Korea

    2 h-index

    12 publications

    656 citations

  3. Nankai University

    Tianjin, China

    2 h-index

    9 publications

    290 citations

  4. Carlsberg Laboratory

    Copenhagen, Denmark

    2 h-index

    6 publications

    182 citations

  5. State Key Laboratory of Microbial Technology

    Jinan, China

    2 h-index

    7 publications

    127 citations

  6. University of California, San Francisco

    San Francisco, United States

    2 h-index

    2 publications

    50 citations

  7. Wrocław University of Science and Technology

    Wroclaw, Poland

    2 h-index

    7 publications

    441 citations

  8. University of California, Riverside

    Riverside, United States

    2 h-index

    3 publications

    401 citations

1–8 of 120

Venues

  1. Biochemistry

    6 publications · 246 citations

    6

    h-index

  2. Journal of the American Chemical Society

    JACS · 5 publications · 384 citations

    5

    h-index

  3. ACS Catalysis

    5 publications · 162 citations

    4

    h-index

  4. Journal of Biological Chemistry

    JBC · 3 publications · 282 citations

    3

    h-index

  5. Journal of Agricultural and Food Chemistry

    3 publications · 63 citations

    3

    h-index

1–5